Km. Kleinow et al., COMPARATIVE PHARMACOKINETICS AND BIOAVAILABILITY OF OXOLINIC ACID IN CHANNEL CATFISH (ICTALURUS-PUNCTATUS) AND RAINBOW-TROUT (ONCORHYNCHUS-MYKISS), Canadian journal of fisheries and aquatic sciences, 51(5), 1994, pp. 1205-1211
The pharmacokinetics, bioavailability, and disposition of oxolinic aci
d (OA), a quinolone antibacterial drug, were examined in a warmwater (
channel catfish (Ictalurus punctatus)) and coldwater fish species (rai
nbow trout (Oncorhynchus mykiss)). Studies were performed at 24 and 14
-degrees-C for catfish and at 14-degrees-C for trout to compare temper
ature- and species-related differences. Analysis of OA pharmacokinetic
s when determined by HPLC provided elimination half-life (t1/2beta), v
olume of distribution (V(ss)), and clearance (Cl(b)) estimates for 24-
degrees-C catfish, 14-degrees-C catfish, and 14-degrees-C trout of 40.
9, 69.3, and 81.3 h, 939, 880, and 1817 mL/kg, and 16.3, 8.9, and 16.9
mL.kg-1.h-1, respectively. Following oral administration, OA plasma c
oncentrations peaked between 8 and 24 h for all treatments; however, 1
4-degrees-C trout and 14-degrees-C catfish sustained peak concentratio
ns for a longer duration than 24-degrees-C catfish. Oral OA bioavailab
ilities were 56.0, 91.8, and 90.7% for 24-degrees-C catfish, 14-degree
s-C catfish, and 14-degrees-C trout, respectively. OA distribution dat
a for muscle of 14-degrees-C catfish demonstrated an inordinately high
peak concentration and delayed time to peak relative to other treatme
nts. Elimination half-lives of OA in muscle were 33.1, 54.3, and 141 h
for 24-degrees-C catfish, 14-degrees-C catfish, and 14-degrees-C trou
t, respectively.