SYNTHESIS OF SOME NEW CHLORO DERIVATIVES OF QUINAZOLINO [4,3-B] QUINAZOLIN-8-ONE AND S-TETRAZOLO [4,3-C] QUINAZOLINE WITH EXPECTED ANTIFUNGICIDAL AND ANTIBACTERIAL ACTIVITIES

Some derivatives of 4-chloro-2-(phenyl or 4-chlorophenyl)-1,3-quinazol ine have been prepared by treating the respective 4(3H) quinazolinone derivatives with POCl3/PCl5. The products were allowed to react with a nthranilic, 5-chloro and 3,5-dichloroanthranilic acid to give new quin azolino [4, 3b] quinazolin-8-ones. On the other hand, the 4-chloro-1,3 -quinazoline derivatives when reacted with NaN3, afforded s-tetrazolo [4,3 c] quinazoline derivatives. These compounds were tested as antifu ngal and antibacterial agents.