APPLICATION OF PIXE METHOD FOR DETERMINAT ION OF TRACE-ELEMENTS IN HUMAN TISSUES

Recently physiological roles of trace elements in the human body in re lation to intoxication and deficiency have attracted much attention fr om investigators in medicine and biology. Particle indeced X-ray emiss ion (PIXE) analysis has high sensitivity for determination of trace el ements in biological and makes it possible to observe the distribution s of trace elements in a small sample simultaneously and non-destructi vely. In this paper, application of the PIXE method to investigate the relation between the elemental distribution and the histological stru cture of the tissues is described. And various concerning diseace-indu ced changes of trace element concentration in tissues are introduced.