CYTOKINE MESSENGER-RNA LEVELS IN MONONUCLEAR BLOOD-CELLS FROM PATIENTS WITH MULTIPLE-SCLEROSIS

Authors
RIECKMANN P ALBRECHT M KITZE B WEBER T TUMANI H BROOCKS A LUER W POSER S
Citation
P. Rieckmann et al., CYTOKINE MESSENGER-RNA LEVELS IN MONONUCLEAR BLOOD-CELLS FROM PATIENTS WITH MULTIPLE-SCLEROSIS, Neurology, 44(8), 1994, pp. 1523-1526
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
44
Issue
8
Year of publication
1994
Pages
1523 - 1526
Database
ISI
SICI code
0028-3878(1994)44:8<1523:CMLIMB>2.0.ZU;2-G
Abstract
We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 45 patients with the relapsing-remitting fo rm of MS and 32 patients with other neurologic diseases. Using a semiq uantitative polymerase chain reaction method, we detected significantl y higher levels of tumor necrosis factor-alpha and lymphotoxin mRNA in patients with relapsing compared to those with stable disease (p < 0. 001), but transforming growth factor-beta and interleukin-10 mRNA expr essions were higher in patients with stable disease.