THE HUMAN PLASMA GLUTATHIONE PEROXIDASE-ENCODING GENE - ORGANIZATION,SEQUENCE AND LOCALIZATION TO CHROMOSOME 5Q32

Authors
YOSHIMURA S SUEMIZU H TANIGUCHI Y ARIMORI K KAWABE N MORIUCHI T
Citation
S. Yoshimura et al., THE HUMAN PLASMA GLUTATHIONE PEROXIDASE-ENCODING GENE - ORGANIZATION,SEQUENCE AND LOCALIZATION TO CHROMOSOME 5Q32, Gene, 145(2), 1994, pp. 293-297
Citations number
18
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
145
Issue
2
Year of publication
1994
Pages
293 - 297
Database
ISI
SICI code
0378-1119(1994)145:2<293:THPGPG>2.0.ZU;2-F
Abstract
A genomic clone encoding the human plasma glutathione peroxidase (PGPx ), a major enzyme in reducing lipid hydroperoxide and hydrogen peroxid e in plasma, was isolated and 5618 nucleotides (nt) were determined. T he nt sequence data revealed that the PGPx gene is composed of five ex ons spanning approx. 10 kb. Primer extension experiments mapped the tr anscription start point at 298 nt upstream from the predicted start co don. Twenty nt upstream from the polyadenylation site of the gene, an uncanonical polyadenylation signal, AGTAAA, was found. Human PGPx was localized on chromosome 5 band q32 by fluorescence in situ hybridizati on.