CLONING AND SEQUENCE-ANALYSIS OF THE HUMAN SNAP25 CDNA

During the screening of human brain-specific cDNAs by a modified diffe rential hybridization analysis, we found a clone which was highly and specifically expressed in the (adult) brain. This clone was subjected to nucleotide sequence analysis and proven to be a nearly full-length cDNA of a human homologue of the previously reported mouse synaptosoma l-associated protein 25 (mSNAP25). The human SNAP25 (hSNAP25) and mSNA P25 showed perfect amino-acid sequence conservation.