RESISTANCE TO INFECTION WITH INTRACELLULAR PARASITES - IDENTIFICATIONOF A CANDIDATE GENE

Authors
VIDAL SM GROS P
Citation
Sm. Vidal et P. Gros, RESISTANCE TO INFECTION WITH INTRACELLULAR PARASITES - IDENTIFICATIONOF A CANDIDATE GENE, News in physiological sciences, 9, 1994, pp. 178-183
Citations number
15
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
9
Year of publication
1994
Pages
178 - 183
Database
ISI
SICI code
0886-1714(1994)9:<178:RTIWIP>2.0.ZU;2-D
Abstract
In the mouse, natural resistance to infection with unrelated intracell ular parasites is controlled by the Bcg locus. With a: positional clon ing approach, a candidate gene for Bcg has been isolated. This gene en codes for a novel macrophage-specific transport protein, Nramp, which is altered in innately susceptible animals.