A NEW ENTRY TO 5-UNSUBSTITUTED 3-ACYLTETRAMIC ACIDS FROM ALDEHYDES

Authors
IIDA T HORI K NOMURA K YOSHII E
Citation
T. Iida et al., A NEW ENTRY TO 5-UNSUBSTITUTED 3-ACYLTETRAMIC ACIDS FROM ALDEHYDES, Heterocycles, 38(8), 1994, pp. 1839-1844
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
38
Issue
8
Year of publication
1994
Pages
1839 - 1844
Database
ISI
SICI code
0385-5414(1994)38:8<1839:ANET53>2.0.ZU;2-H
Abstract
Reaction of aldehydes (prim-, sec-, and tert-) with diazoacetamide (8, 9) of N-substituted glycinate in the presence of Zr(IV) chloride in C H2Cl2 affords beta-keto amides (11, 12) in good to high yields, which on treatment with n-Bu4NF in THF are led to N-protected 3-acyltetramic acids (13, 14).