TRANSFORMING GROWTH-FACTOR-ALPHA AND EPIDERMAL GROWTH-FACTOR STIMULATE OLIGOMERIZATION AND AUTOPHOSPHORYLATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN A-431 LIVING CELLS

Authors
KULIK GA KARTEL AA KONONENKO LI TARNAVSKI DV POGREBNOY PV BYKOREZ AI
Citation
Ga. Kulik et al., TRANSFORMING GROWTH-FACTOR-ALPHA AND EPIDERMAL GROWTH-FACTOR STIMULATE OLIGOMERIZATION AND AUTOPHOSPHORYLATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN A-431 LIVING CELLS, Eksperimental'naa onkologia, 16(1), 1994, pp. 33-36
Citations number
17
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
16
Issue
1
Year of publication
1994
Pages
33 - 36
Database
ISI
SICI code
0204-3564(1994)16:1<33:TGAEGS>2.0.ZU;2-B
Abstract
Transforming growth factor alpha (TGF-alpha) and epidermal growth fact or (EGF) stimulated autophosphorylation of epidermal growth factor rec eptor (EGFR) in plasma membrane preparations and A-431 living cells ha ve been studied. EGF and TGF-alpha concentrations possessing the same I-125-EGF displacement activity stimulate EGFR autophosphorylation to different extent. In the case of EGF stimulation, autophosphorylation of EGFR reached plato at more narrow concentration range than for TGF- alpha. Both ligands were found to induce dimerization of EGFR in livin g cells.