MURINE AIDS PROTECTS MICE AGAINST EXPERIMENTAL CEREBRAL MALARIA - DOWN-REGULATION BY INTERLEUKIN-10 OF A T-HELPER TYPE-1 CD4-MEDIATED PATHOLOGY( CELL)

Authors
ECKWALANGA M MARUSSIG M TAVARES MD BOUANGA JC HULIER E PAVLOVITCH JH MINOPRIO P PORTNOI D RENIA L MAZIER D
Citation
M. Eckwalanga et al., MURINE AIDS PROTECTS MICE AGAINST EXPERIMENTAL CEREBRAL MALARIA - DOWN-REGULATION BY INTERLEUKIN-10 OF A T-HELPER TYPE-1 CD4-MEDIATED PATHOLOGY( CELL), Proceedings of the National Academy of Sciences of the United Statesof America, 91(17), 1994, pp. 8097-8101
Citations number
48
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
91
Issue
17
Year of publication
1994
Pages
8097 - 8101
Database
ISI
SICI code
0027-8424(1994)91:17<8097:MAPMAE>2.0.ZU;2-K
Abstract
The retrovirus LP-BM5 murine leukemia virus induces murine AIDS in C57 BL/6 mice that has many similarities with human AIDS; Plasmodium bergh ei ANKA causes experimental cerebral malaria in the same strain of mir e. The outcome of malaria infection was studied in mice concurrently i nfected with the two pathogens. The retrovirus significantly reduced t he gravity of the neurological manifestations associated with Plasmodi um berghei ANKA infection. The protection against experimental cerebra l malaria induced by murine AIDS increased with duration of viral infe ction and, hence, with the severity of the immunodeficiency. Interleuk in 10, principally from splenic T cells, was shown to play a crucial r ole in this protection.