EFFECT OF CORTICOSTEROID-THERAPY ON HUMAN IMMUNODEFICIENCY VIRUS-ASSOCIATED NEPHROPATHY

PURPOSE: Human immunodeficiency virus-associated nephropathy (HIV-AN) occurs predominantly in blacks and is characterized histologically by focal segmental glomerulosclerosis or mesangial proliferation and a ly mphohistiocytic tubulointerstitial infiltrate. Patients manifest heavy proteinuria and, once azotemia occurs, progress rapidly to end-stage renal disease within 2 to 6 months. No treatment has been shown to be useful for HIV-AN. The purpose of this study was to determine the effe ct of corticosteroid agents on the progression of HIV-AN. PATIENTS AND METHODS: Four consecutive HIV-infected adults with fewer than 200 CD4 cells/mu L, moderate to severe renal insufficiency, proteinuria great er than 2 g per 24 hours, and HIV-AN demonstrated by renal biopsy were treated with 60 mg of prednisone daily for 2 to 6 weeks. Patients wer e followed with respect to serum creatinine level, 24-hour protein exc retion, adverse drug reactions, and the occurrence of opportunistic in fections. RESULTS: CD4 counts ranged from 30 to 80 cells/mu L before t herapy with steroids. The mean (+/- SD) pretreatment serum creatine co ncentration was 9.1 +/- 5.7 mg/dL and decreased to 3.3 +/- 1.8 mg/dL ( P < 0.05) after 2 to 6 weeks of corticosteroid therapy. Twenty-four ho ur protein excretion did not change (5.2 +/- 2.4 g pretreatment versus 4.6 +/- 4.1 g posttreatment). One patient was able to discontinue dia lysis after 10 days. Two patients developed Mycobacterium avium-comple x infections and steroid-associated psychosis. One of these patients d eveloped a recurrence of genital herpes, and the other developed derma tomal tester. None of the four required dialysis during a 1.5- to 5.5- month period of follow-up after cessation of steroid treatment. CONCLU SION: In Selected patients with HIV-AN, short-term treatment with cort icosteroid agents improves renal function and prevents the development of end-stage renal disease during a 1.5- to 5.5-month period of obser vation, but may be associated with an increased risk of opportunistic infection.