POTENT ANTIFUNGAL EFFECTS OF A NEW DERIVATIVE OF PARTRICIN-A IN A MURINE MODEL OF CEREBRAL CRYPTOCOCCOSIS

Authors
LUNA T MAZZOLLA R ROMANO G BLASI E
Citation
T. Luna et al., POTENT ANTIFUNGAL EFFECTS OF A NEW DERIVATIVE OF PARTRICIN-A IN A MURINE MODEL OF CEREBRAL CRYPTOCOCCOSIS, Antimicrobial agents and chemotherapy, 41(3), 1997, pp. 706-708
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
3
Year of publication
1997
Pages
706 - 708
Database
ISI
SICI code
0066-4804(1997)41:3<706:PAEOAN>2.0.ZU;2-6
Abstract
A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA),was investigated and was f ound to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitr o by potentiating the anticryptococcal activity of murine microglial c ells.