COMPARISON OF THE IN-VITRO ACTIVITIES OF BAY-12-8039, A NEW QUINOLONE, AND OTHER ANTIMICROBIALS AGAINST CLINICALLY IMPORTANT ANAEROBES

Bay 12-8039, a new 8-methoxy quinolone, was compared with other agents for activity against clinically relevant anaerobes. Bay 12-8039 inhib ited 91 and 96% of the 410 test isolates at 2 and 4 mu g/ml, respectiv ely. Bay 12-8039 had activity comparable to that of metronidazole and overall was at least 16-fold more active than ciprofloxacin, ofloxacin , and cefoxitin, 32-fold more active than cefotetan, and at least 128- fold more active than penicillin G.