DIRECT EVIDENCE FOR UPTAKE OF INTACT LIPOSOMES ENCAPSULATING SILVER SULFADIAZINE BY CULTURED HUMAN KERATINOCYTES BASED ON COMBINED TRANSMISSION ELECTRON-MICROSCOPY AND X-RAY-MICROANALYSIS

Authors
SCHALLER M WURM R KORTING HC
Citation
M. Schaller et al., DIRECT EVIDENCE FOR UPTAKE OF INTACT LIPOSOMES ENCAPSULATING SILVER SULFADIAZINE BY CULTURED HUMAN KERATINOCYTES BASED ON COMBINED TRANSMISSION ELECTRON-MICROSCOPY AND X-RAY-MICROANALYSIS, Antimicrobial agents and chemotherapy, 41(3), 1997, pp. 717-719
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
3
Year of publication
1997
Pages
717 - 719
Database
ISI
SICI code
0066-4804(1997)41:3<717:DEFUOI>2.0.ZU;2-L
Abstract
Cultured human keratinocytes were exposed to liposomally encapsulated silver sulfadiazine, free silver sulfadiazine, silver sulfadiazine cre am, and a corresponding vehicle for 5 min to 24 h. Phagocytosis of int act liposomes by keratinocytes was demonstrated in vitro by combined X -ray microanalysis and electron microscopy. Silver as an active part o f the antimicrobial served as an electron-dense marker.