A 10-year-old girl with a lumbosacral myelomeningocele, managed with c
lean intermittent catheterization, presented with headache, vomiting,
and lethargy. The cerebrospinal fluid (CSF) and urine cultures reveale
d Escherichia coli, documented to be the same subtype. The organisms w
ere subtyped and the E. coli from both the urine and CSF were noted to
be of the same strain. Management consisted of intravenous antibiotic
s and ultimate replacement of the ventriculoperitoneal shunt. Children
with myelodysplasia and CSF shunts should be carefully monitored in a
multidisciplinary fashion to anticipate, correctly diagnose, and trea
t CSF shunt infections associated with bacteriuria.