CIRCADIAN VARIATIONS IN HIGH BLOOD-PRESSURE-LOWERING EFFECTS OF CLONIDINE AND ALPHA-METHYL DOPA

Authors
YEGNANARAYAN R BALWANI JH
Citation
R. Yegnanarayan et Jh. Balwani, CIRCADIAN VARIATIONS IN HIGH BLOOD-PRESSURE-LOWERING EFFECTS OF CLONIDINE AND ALPHA-METHYL DOPA, Biological rhythm research, 25(3), 1994, pp. 329-340
Citations number
25
Categorie Soggetti
Biology,Physiology
Journal title
Biological rhythm research → ACNP
ISSN journal
09291016
Volume
25
Issue
3
Year of publication
1994
Pages
329 - 340
Database
ISI
SICI code
0929-1016(1994)25:3<329:CVIHBE>2.0.ZU;2-M
Abstract
Two antihypertensive agents - clonidine and alpha methyl dopa were adm inistered to hypertensive patients as a single dose at four fixed time points: 08:00, 12:00, 16:00, 20:00. The magnitude of fall in blood pr essure, the peak and duration of effect varied significantly with the time of administration, the blood pressure lowering response being gre ater during the morning hours. Administration at 16:00 did not produce a satisfactory fall in blood pressure. A circadian rhythm was demonst rated for standing blood pressure change with both clonidine and alpha methyl dopa.