GIANT-CELL TUMOR OF THE LARYNX - CASE-REPORT AND REVIEW OF THE LITERATURE

Giant cell tumor of bone is rare in the osteocartilaginous tissues of the larynx. We describe a 23-year-old man with a 6-month history of pr ogressive hoarseness and an enlarging neck mass. Computed tomography d emonstrated a 4-cm mass with central cystic change arising in the righ t ala of the thyroid cartilage. A hemilaryngectomy was performed. Gros sly, the lesion was expansile and circumscribed, but unencapsulated. O n microscopic examination, numerous multinucleated giant cells were ev enly dispersed within a cellular and vascular stroma. The findings wer e characteristic of giant cell tumor of bone. The patient has been dis ease free for 56 months. A review of the international literature yiel ded 11 cases. No lesion is known to have recurred after surgical excis ion, irradiation, or both. We present a clinicopathologic analysis of giant cell tumors involving the larynx and conclude that giant cell tu mors are associated with a favorable clinical outcome.