SYNTHESIS OF THE TAXOL DERIVATIVES - CONTROL OF ATROPISOMERISM

Authors
NAKAMURA T WAIZUMI N TSURUTA K HORIGUCHI Y KUWAJIMA I
Citation
T. Nakamura et al., SYNTHESIS OF THE TAXOL DERIVATIVES - CONTROL OF ATROPISOMERISM, Synlett, (8), 1994, pp. 584-586
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
8
Year of publication
1994
Pages
584 - 586
Database
ISI
SICI code
0936-5214(1994):8<584:SOTTD->2.0.ZU;2-A
Abstract
An efficient synthesis of taxol derivatives was accomplished by the Le wis acid mediated intramolecular coupling of the dienol silyl ether an d the acetal, in which controlling the atropisomerism of the cyclizati on precursor is crucial.