Authors
Citation
I. Ryu et al., A N-RADICAL CARBONYLATION(1 STRATEGY FOR MACROCYCLIZATION BASED ON FREE), Synlett, (8), 1994, pp. 643-644
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
ISSN journal
09365214
Issue
8
Year of publication
1994
Pages
643 - 644
Database
ISI
SICI code
0936-5214(1994):8<643:ANCSFM>2.0.ZU;2-T
Abstract
The synthesis of 10-17 membered 4-oxolactones 2 from alkyl iodides 1 h
aving an acryloxy moiety at the termini, carbon monoxide, and TTMSS (o
r tin hydride) takes place cleanly in moderate to good yield under fre
e radical conditions. Low concentrations of 1 (0.005-0.01 M) are favor
able for both intermolecular trap of CO and intramolecular acyl radica
l addition to the C-C double bond,