CHARACTERIZATION OF CATIONIC POLYELECTROLYTE-INDUCED DOMAINS IN MIXEDPOPG-POPC LIPID BILAYERS VIA H-2 NMR

Authors
CROWELL KJ MACDONALD PM
Citation
Kj. Crowell et Pm. Macdonald, CHARACTERIZATION OF CATIONIC POLYELECTROLYTE-INDUCED DOMAINS IN MIXEDPOPG-POPC LIPID BILAYERS VIA H-2 NMR, JOURNAL OF PHYSICAL CHEMISTRY B, 101(7), 1997, pp. 1105-1109
Citations number
25
Categorie Soggetti
Chemistry Physical
Journal title
JOURNAL OF PHYSICAL CHEMISTRY B
ISSN journal
15206106 → ACNP
Volume
101
Issue
7
Year of publication
1997
Pages
1105 - 1109
Database
ISI
SICI code
1089-5647(1997)101:7<1105:COCPDI>2.0.ZU;2-N
Abstract
The interactions of a cationic polyelectrolyte, poly(vinylbenzyltrimet hylammonium chloride) (PVTA), with anionic lipid bilayer membranes com posed of a mixture of phosphatidylglycerol (POPG) plus phosphatidylcho line (POPC) have been examined using H-2 NMR of choline-deuterated POP C to probe membrane surface electrostatics. PVTA produces distinct mem brane domains containing a 1:1 PVTA/POPG cation/anion charge ratio. Th e remaining PVTA-free domains are depleted with respect to POPG.