SYNTHESIS AND REACTIONS OF MINO-4-ARYL-5,6,7,8-TETRABROMO-1(2H)-PHTHALAZINONE DERIVATIVES

Authors
FIKRY RM YASSIN FA MOHAMED EK
Citation
Rm. Fikry et al., SYNTHESIS AND REACTIONS OF MINO-4-ARYL-5,6,7,8-TETRABROMO-1(2H)-PHTHALAZINONE DERIVATIVES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 33(8), 1994, pp. 742-746
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
33
Issue
8
Year of publication
1994
Pages
742 - 746
Database
ISI
SICI code
0376-4699(1994)33:8<742:SAROM>2.0.ZU;2-5
Abstract
ino-4-aryl-5,6,7,8-tetrabromo-1(2H)-phthalazinones (3a-c) have been pr epared via the interaction of benzoxazones (2a-c) with, hydrazine hydr ate in boiling pyridine. The reaction of 3a with carbon disulphide and hydrazine hydrate in the presence of liquid ammonia gives 2-thiosemic arbazide phthalazinone derivative 4. Also, the reaction of 3a separate ly with phenyl isothiocyanate, chloroacetyl chloride and alpha-chloroa cetanilide gives the corresponding N-phenylaminocarbothiamido-, alpha- chloroacetamido, and N-phenylcarbamoylmcthylaminophthalazinones (6, 9, 11). The biological activity of some compounds has been described.