IVERMECTIN LEVELS VARY IN TISSUES AND SPECIES

Ivermectin (IVM) is high in faeces, not found in urine but low in skin , saliva and breastmilk of man. Plasmo levels vary according to specie s. Binding to plasma proteins varies also. Resistance of some form ani mal nematodes to the avermectins have been reported. A small percentag e of patients show poor reduction in skin mf after yearly treatment wi th ivermectin. We suggest that tissue bioavailability of free drug mus t be ascertained before interpreting animal models and chemotherapy pr ograms.