PARENTERAL ADMINISTRATION OF CYTOKINES AND DRUGS IN RODENT FILARIASISVIA OSMOTIC PUMPS

Changes in the cytokine production profile are supposed to be responsi ble for the different courses of parasitic infections. Therefore, a bi g effort is mode to understand the roles of cytokines produced by diff erent cells during parasitic infections, In the following text we desc ribe first experiments with Interferon-gamma done in a natural model f or filariasis, the filariae Mononema martini in Lemniscomys striatus. For the application of this cytokine to the animals we implanted osmot ic pumps, which deliver IFN-gamma continuously.