STUDIES ON ANTIGENS OF THE RODENT FILARIA ACANTHOCHEILONEMA-VITEAE WITH HOMOLOGY TO ANTIGENS OF ONCHOCERCA-VOLVULUS

Authors
LUCIUS R HOFLE W LIERAU S BRADLEY J WILLENBUCHER J
Citation
R. Lucius et al., STUDIES ON ANTIGENS OF THE RODENT FILARIA ACANTHOCHEILONEMA-VITEAE WITH HOMOLOGY TO ANTIGENS OF ONCHOCERCA-VOLVULUS, Parasite, 1, 1994, pp. 48-49
Citations number
11
Categorie Soggetti
Parasitiology
Journal title
Parasite → ACNP
ISSN journal
1252607X
Volume
1
Year of publication
1994
Supplement
1
Pages
48 - 49
Database
ISI
SICI code
1252-607X(1994)1:<48:SOAOTR>2.0.ZU;2-J
Abstract
To perform studies on the role of filarial proteins in the host-parasi te-relationship and on their biological function we cloned and express ed proteins of A. viteae with homology to known O. volvulus proteins. Av33, as well as its O. volvulus-homolog Ov33, showed a homology to an aspartyl protease inhibitor of Ascaris suum. Av33 was secreted by adu lt worms and was not host protective. A. viteae-Cystatin, a homolog of the cysteine proteinase inhibitor onchocystatin, was expressed as an active inhibitor. The molecule was secreted by various parasite stages and was not host protective. We have hints for a macrophage modulatin g role of the antigen. Three other cloned A. viteae antigens are curre ntly under investigation.