POTENTIAL ANTIMALARIALS .21. MANNICH BASE DERIVATIVES OF 4-[7-CHLORO(AND 7-TRIFLUOROMETHYL)QUINOLIN-4-YLAMINO]PHENOLS

Authors
BARLIN GB IRELAND SJ NGUYEN TMT KOTECKA B RIECKMANN KH
Citation
Gb. Barlin et al., POTENTIAL ANTIMALARIALS .21. MANNICH BASE DERIVATIVES OF 4-[7-CHLORO(AND 7-TRIFLUOROMETHYL)QUINOLIN-4-YLAMINO]PHENOLS, Australian Journal of Chemistry, 47(8), 1994, pp. 1553-1560
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Australian Journal of Chemistry → ACNP
ISSN journal
00049425
Volume
47
Issue
8
Year of publication
1994
Pages
1553 - 1560
Database
ISI
SICI code
0004-9425(1994)47:8<1553:PA.MBD>2.0.ZU;2-T
Abstract
Syntheses are reported for lin-4-ylamino)-2,6-bis(piperidin-1-ylmethyl )phenol (2) and its 3-fluoro and 3-piperidinyl derivatives. Some mono- Mannich analogues with 2-fluoro, 2-t-butyl and 3-trifluoromethyl subst ituents have also been prepared. In tests for antimalarial activity ag ainst the FC-27 and K-1 isolates of Plasmodium falciparum in vitro, co mpound (2) proved to be the most active (IC50 6.3-12.5 nm).