PHARMACOKINETICS AND PHARMACODYNAMICS OF ROCURONIUM IN PATIENTS WITH CIRRHOSIS (REPRINTED FROM ANESTHESIOLOGY, VOL 80, 1994)

Authors
KHALIL M DHONNEUR G DUVALDESTIN P SLAVOV V DEHYS C GOMENI R
Citation
M. Khalil et al., PHARMACOKINETICS AND PHARMACODYNAMICS OF ROCURONIUM IN PATIENTS WITH CIRRHOSIS (REPRINTED FROM ANESTHESIOLOGY, VOL 80, 1994), European journal of anaesthesiology, 1994, pp. 85-86
Citations number
NO
Categorie Soggetti
Anesthesiology
Journal title
European journal of anaesthesiology → ACNP
ISSN journal
02650215
Year of publication
1994
Supplement
9
Pages
85 - 86
Database
ISI
SICI code
0265-0215(1994):<85:PAPORI>2.0.ZU;2-B
Abstract
The pharmacokinetics of rocuronium in 1 0 patients with proven cirrhos is were compared with those in eight normal patients. Patients with ci rrhosis had an increased volume of the central compartment and this wa s associated with a lower maximum block in several patients with a slo wer onset and longer recovery index. Other pharmacokinetic parameters did not differ significantly between the groups, suggesting that hepat ic elimination is not a significant factor in the removal of rocuroniu m.