REDUCTION OF THE RETENTION OF PU-238 INHALED AS THE TRIBUTYLPHOSPHATECOMPLEX IN RATS TREATED BY 3,4,3-LIHOPO

Authors
PAQUET F PONCY JL RATEAU G BURGADA R BAILLY T LEROUX Y RAYMOND KN DURBIN PW MASSE R
Citation
F. Paquet et al., REDUCTION OF THE RETENTION OF PU-238 INHALED AS THE TRIBUTYLPHOSPHATECOMPLEX IN RATS TREATED BY 3,4,3-LIHOPO, Radiation protection dosimetry, 53(1-4), 1994, pp. 323-326
Citations number
NO
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Nuclear Sciences & Tecnology
Journal title
Radiation protection dosimetry → ACNP
ISSN journal
01448420
Volume
53
Issue
1-4
Year of publication
1994
Pages
323 - 326
Database
ISI
SICI code
0144-8420(1994)53:1-4<323:ROTROP>2.0.ZU;2-U
Abstract
The ability of 3,4,3-LIHOPO, used at a dosage of 3 mumol.kg-1 of body weight, has been tested in Sprague-Dawley rats for reducing the retent ion of plutonium after inhalation of Pu-238-TBP. The comparison was ma de with DTPA, the reference substance for treatment in man. With low l ung deposit (about 7 kBq) it was shown that the 3,4,3-LIHOPO was alway s more effective than DTPA, even at lower dosage. When the contaminati on level was higher (25 kBq) DTPA was more effective. In each case, th e importance of prompt treatment after contamination is emphasised.