Y. Ichimasa et al., IN-VITRO DETERMINATION OF AGE-DEPENDENCE OF OXIDATION OF TRITIUM GAS IN RATS, Radiation protection dosimetry, 53(1-4), 1994, pp. 339-342
Citations number
NO
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Nuclear Sciences & Tecnology
Age dependence of tritium gas (HT) oxidation in rats was investigated
in in vitro experiments using faecal suspensions and intestinal conten
ts from rats. HT oxidation was determined as the fixation of HT in fae
ces or intestinal contents suspended with GAM medium at 30-degrees-C u
nder anaerobic and aerobic conditions. The HT oxidation rate in faecal
suspension under anaerobic conditions was almost constant irrespectiv
e of age and about 10 times that under aerobic conditions in 10 to 100
week old rats. The viable cell number of anaerobic microbes in faeces
was 3-4 times that of aerobic microbes (facultative anaerobes) and te
nded to decrease with age in each case. The HT oxidation activity of i
ntestinal contents was highest in the caecum contents and rectum conte
nts under anaerobic conditions, almost the same as that in faeces and
nearly constant irrespective of age, and about 10 times that in the re
ctum contents under aerobic conditions. The calculated HT fixation rat
e (HT --> HTO per g body water) was greatest in 4 week old animals, ab
out 4 times that at 2 weeks of age, and showed a slight decrease in ol
der animals.