INTERACTION OF SOME ANTI-HYPOXIA DRUGS WITH HYDROXYPROPYL-BETA-CYCLODEXTRIN STUDIED BY MEANS OF CHARGE-TRANSFER CHROMATOGRAPHY

The interaction of 12 anti-hypoxia drugs with hydroxypropyl-beta-cyclo dextrin (HPBCD) and the influence of LiCl, NaCl and KCl on the strengt h of interaction was studied by charge transfer chromatography. Most o f the drugs form inclusion complexes with HPBCD and the relative stren gth of interaction varies markedly according to the structure of the d rugs. Salts exert a considerable influence on the inclusion complex fo rmation and the effect depends on the radii of the cation. The signifi cant correlations between the lipophilicity of drugs and their capacit y to form inclusion complexes with HPBCD indicate the involvement of h ydrophobic forces in the interaction.