Human findings indicate that the most important brain regions in the e
lectrogenesis of the P3 event-related potential component are the junc
tion of the parieto-temporal lobes, parts of the limbic system and som
e parts of the thalamus. Data collected in animal experiments support
the results of the human studies emphasizing the role of the associati
on cortical areas, that of limbic structures and possibly of some thal
amic nuclei. It is not clear as yet how the activity of these hypothes
ized generators are integrated and to what extent, and how they contri
bute to the scalp-recorded P3.