INCREASED ACTIVATION OF 2',3'-DIDEOXYCYTIDINE BY ACTVICIN

Authors
AGARWAL RP
Citation
Rp. Agarwal, INCREASED ACTIVATION OF 2',3'-DIDEOXYCYTIDINE BY ACTVICIN, Biochemical and biophysical research communications, 202(3), 1994, pp. 1524-1529
Citations number
20
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
202
Issue
3
Year of publication
1994
Pages
1524 - 1529
Database
ISI
SICI code
0006-291X(1994)202:3<1524:IAO2BA>2.0.ZU;2-7
Abstract
The effect of acivicin (ACV) on cell growth, cell cycle progression, a nd intracellular accumulation of 2',3'-dideoxycytidine (ddC) was exami ned. Treatment of H9 cells with ACV (1 mu M) plus ddC (25 mu M) for 24 hrs inhibited cell growth to 74 +/- 7%, arrested cells in the S phase , and increased the cellular ddC accumulation to 195-208% of control. The concentrations of ddCTP, the active form of ddC, was increased 3.4 fold in ACV treated cells. (C) 1994 Academic Press, Inc.