ROLE OF NATURAL-KILLER-CELLS IN INNATE RESISTANCE TO PROTOZOAN INFECTIONS

Authors
SCHARTONKERSTEN TM SHER A
Citation
Tm. Schartonkersten et A. Sher, ROLE OF NATURAL-KILLER-CELLS IN INNATE RESISTANCE TO PROTOZOAN INFECTIONS, Current opinion in immunology, 9(1), 1997, pp. 44-51
Citations number
86
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
9
Issue
1
Year of publication
1997
Pages
44 - 51
Database
ISI
SICI code
0952-7915(1997)9:1<44:RONIIR>2.0.ZU;2-D
Abstract
Natural killer cells are now recognized as major effectors of innate r esistance to protozoan parasites. The principal mechanism by which the y control the growth of these pathogens is indirect, involving cytokin e production rather than cytolytic activity. Recent studies have ident ified a series of positive and negative signals provided by cytokines and cellular interactions which regulate protozoa-induced natural kill er cell function.