REGULATION OF TRANSCRIPTION OF MHC CLASS-II GENES

Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II g enes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a l imiting molecular switch that is responsible for the control of class II expression and the regulation of expression by interferon-gamma.