COMPARISON OF PLASMA PCR AND BRONCHOALVEOLAR LAVAGE FLUID CULTURE FORDETECTION OF CYTOMEGALOVIRUS-INFECTION IN ADULT BONE-MARROW TRANSPLANT RECIPIENTS

Authors
ASPIN MM GALLEZHAWKINS GM GIUGNI TD TEGTMEIER B LANG DJ SCHMIDT GM FORMAN SJ ZAIA JA
Citation
Mm. Aspin et al., COMPARISON OF PLASMA PCR AND BRONCHOALVEOLAR LAVAGE FLUID CULTURE FORDETECTION OF CYTOMEGALOVIRUS-INFECTION IN ADULT BONE-MARROW TRANSPLANT RECIPIENTS, Journal of clinical microbiology, 32(9), 1994, pp. 2266-2269
Citations number
28
Categorie Soggetti
Microbiology
Journal title
Journal of clinical microbiology → ACNP
ISSN journal
00951137
Volume
32
Issue
9
Year of publication
1994
Pages
2266 - 2269
Database
ISI
SICI code
0095-1137(1994)32:9<2266:COPPAB>2.0.ZU;2-Z
Abstract
Plasma PCR for human cytomegalovirus (CMV) DNA was compared with bronc hoalveolar lavage (BAL) fluid culture as an indicator for disseminated CMV infection. Thirteen (32.5%) of 40 consecutive bone marrow transpl ant (BMT) recipients were BAL fluid culture positive for CMV on day 35 post-BMT, and 9 (69%) of the 13 had positive plasma PCRs between days 28 and 49. Of the 27 with negative BAL fluid cultures, 2 (7%) had pos itive plasma PCRs (P < 0.0001). Plasma CMV DNA in BMT recipients is a useful clinical marker for serious infection.