DEMONSTRATION OF PERSISTENCE OF SALMONELLA-TYPHIMURIUM IN AN AIDS PATIENT BY MOLECULAR METHODS

We document microbiological persistence of the same Salmonella typhimu rium strain in an AIDS patient during 7 months of clinical observation despite prolonged quinolone therapy. Persistence was demonstrated by phage types that closely resembled one another, similar antibiotic res istance patterns, conserved restriction fragment length polymorphism o f chromosomal DNA digested with different DNA restriction enzymes, ide ntical ribotypes, and IS200 types in four characterized sequential iso lates of S. typhimurium.