RESISTANCE TO AZIDOTHYMIDINE IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION (A REVIEW)

Authors
KARAMOV EV LUKASHOV VV
Citation
Ev. Karamov et Vv. Lukashov, RESISTANCE TO AZIDOTHYMIDINE IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION (A REVIEW), Molecular biology, 28(1), 1994, pp. 1-10
Citations number
75
Categorie Soggetti
Biology
Journal title
Molecular biology → ACNP
ISSN journal
00268933
Volume
28
Issue
1
Year of publication
1994
Part
1
Pages
1 - 10
Database
ISI
SICI code
0026-8933(1994)28:1<1:RTAIHI>2.0.ZU;2-J
Abstract
The phenomenon of AZT resistance during the infection by human immunod eficiency virus (HN) is discussed in this review. Different aspects of AZT resistance, including biological and virological characteristics of resistant HIV isolates, genetic mechanisms of resistance, cross-res istance to other nucleoside analogs and non-nucleoside inhibitors are analyzed. The role of target cells in AZT resistance is also considere d.