Va. Murrah et Jg. Batsakis, PROLIFERATIVE VERRUCOUS LEUKOPLAKIA AND VERRUCOUS HYPERPLASIA, The Annals of otology, rhinology & laryngology, 103(8), 1994, pp. 660-663
Proliferative verrucous leukoplakia and hyperplasia are irreversible c
linicopathologic lesions of the oral cavity and upper respiratory trac
t with considerable potential for evolving into verrucous or other for
ms of squamous cell carcinoma. Proliferative vermcous leukoplakia is a
disease of the oral cavity in which vermcous hyperplasia is a part of
its developmental spectrum. Verrucous hyperplasia, at other head and
neck mucosal sites, may be associated with papillomas or be a de novo
lesion. Human papillomavirus, as a cofactor, plays a role in some of t
he lesions. In the instance of vermcous hyperplasia, the authors consi
der it an early form of vermcous carcinoma and recommend it be treated
accordingly.