At. James et al., RANDOM EFFECTS AND VARIANCES AS A SYNTHESIS OF NONLINEAR-REGRESSION ANALYSES OF MITOCHONDRIAL ELECTRON-TRANSPORT, Biometrika, 81(2), 1994, pp. 219-235
Citations number
9
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Statistic & Probability
This cross-disciplinary paper develops random effects and variances me
thods, especially for small samples within effects, and applies them t
o mitochondrial enzyme kinetics. A new force flux kinetic model is int
roduced for the alternative oxidase of plant mitochondria, the results
of 42 experiments are published and the force flux function is fitted
by nonlinear regression for each experiment. The results of the regre
ssion analyses are synthesized by a random effects model specifying ra
ndom nonlinear regression coefficients and random variances within exp
eriments distributed in an inverse gamma distribution.