SUCRALFATE - THE BANGKOK REVIEW

Sucralfate is a site-protective ulcer healing drug with a remarkable r ange of mechanisms of action. Recent studies highlight the capacity of sucralfate to bind basic fibroblast growth factor (bFGF) and deliver it in high concentration to the ulcer. Basic fibroblast growth factor stimulates the production of granulation tissue, angiogenesis and re-e pithelization, thus improving the quality of ulcer healing. The effect of sucralfate in reducing parietal cell sensitivity may be another fa ctor important in the lower relapse rate demonstrated after duodenal u lcer healing. Sucralfate has been demonstrated to be efficacious in he aling both duodenal and gastric ulcers together with mild oesophagitis , and it is safe for both short-term use and maintenance. In stress ul cer prophylaxis it is as effective as acid suppression or neutralizati on and has the advantage of lesser rates of nosocomial pneumonia than are demonstrated with antacids or H2 antagonists. The potential advant ages of sucralfate lie in the better quality of ulcer healing associat ed with longer duration of remission.