HEPATITIS-C AND HEPATITIS-B VIRUS-INFECTIONS IN POPULATIONS AT LOW ORHIGH-RISK IN HO-CHI-MINH AND HANOI, VIETNAM

Inhabitants and patients of two cities in Vietnam were tested for anti bodies to hepatitis C virus (anti-HCV), hepatitis B surface antigen (H BsAg) and antibody to HBsAg (anti-HBs). Anti-HCV was detected in 43 (9 %) of 491 individuals without liver disease in Ho Chi Minh, more frequ ently (P < 0.001) than in 18 (4%) of 511 in Hanoi. There was no appare nt age-specific distribution of anti-HCV. Among inhabitants of both ci ties, HBsAg and anti-HBs were frequent, detected in 10-14% and 35-37%, respectively; the prevalence of anti-HBs increased in parallel with a ge. Among individuals at high risk, the prevalence of anti-HCV was par ticularly high in drug users (58/67 or 87%) and patients on maintenanc e haemodialysis (15/28 or 54%) or with haemophilia (7/24 or 29%) in Ho Chi Minh, and in drug users in Hanoi (61/200 or 31%). Prevalence of H BsAg and anti-HBs in high-risk groups was not different from those in the general population. Screening of anti-HCV in blood donors in Vietn am is of urgent necessity because blood supply is dependent on commerc ial blood donors, many of whom are drug users at high risk.