AUDITORY STARTLE IN SWISS WEBSTER MICE FED EXCESS ALUMINUM IN DIET

Using an automated method, reduced auditory startle responsiveness was detected in Swiss Webster mice fed excess aluminum in diet (1000 mug Al/g) as compared to controls (7 mug Al/g). Excess aluminum diets were fed either from conception to weaning (developmental group) or from c onception and continuing to 52 days of age (continuous group). At 22 d ays of age, lower response amplitudes were seen in the aluminum expose d groups than in controls. At 52 days of age, more rapid reduction in response amplitude across initial trial blocks was noted. Effects were more prominent in the continuously exposed than the developmentally ' 'posed group at 52 days of age. Reduced auditory startle responsivenes s is interpreted as part of a pattern of subtle motor impairment and m arginally reduced activity and responsiveness in mice fed excess alumi num in diet.