THE SIMULTANEOUS ANALYSIS OF THEOPHYLLINE, CAFFEINE AND THEIR METABOLITES IN HUMAN PLASMA BY HPLC

Authors
SAMO AR ARBANI SA KHAHAWER MY CHIPPA MA QURESHI GA
Citation
Ar. Samo et al., THE SIMULTANEOUS ANALYSIS OF THEOPHYLLINE, CAFFEINE AND THEIR METABOLITES IN HUMAN PLASMA BY HPLC, Journal of the Chemical Society of Pakistan, 15(3), 1993, pp. 182-186
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society of Pakistan → ACNP
ISSN journal
02535106
Volume
15
Issue
3
Year of publication
1993
Pages
182 - 186
Database
ISI
SICI code
0253-5106(1993)15:3<182:TSAOTC>2.0.ZU;2-C
Abstract
Theoplline, caffeine and their important metabolites were extracted fr om human plasma using newly developed solid support liquid/liquid extr action tubes. These substances were separated on a 3 mum ODS (250 x 4. 6 mm i.d) column with a mobile phase gradient and detected with a UV d iode array detector set at two wave lengths of 270 and 290 nm. The nor mal ranges for the plasma drug/metabolite molar ratios have been deter mined.