CIRCULAR-DICHROISM STUDIES ON COMPLEX-FORMING ABILITY OF ANTIBIOTIC D-CYCLOSERINE WITH VO(IV), CO(II) AND NI(II) IONS IN AQUEOUS-SOLUTION

CD studies have been utilized to investigate complex forming ability o f antibiotic (+)-cycloserine (CCS) With VO2+, Co2+ and Ni2+ ions in aq ueous solution. In solution, complex ions of the type [M(CCS)3]2+ are formed at pH 4.0 which show 2-3 Co''on bands between 16,129-28,011 cm- 1 with molar ellipticity values 59.0-1838.6 dm3 mo-1 cm-1. At optimum conditions intensity of CD bands is linearly increased with concentrat ion of the components between 1-10 x 10(-2) mol dm-3. CD bands are ass igned to electronic transitions corresponding to lower symmetry of oct ahedral complexes.