HEMOLYSIS AND AUTOANTIBODIES TO TRIOSEPHOSPHATE ISOMERASE IN A PATIENT WITH ACUTE HEPATITIS-A VIRUS-INFECTION

Authors
RITTER K UY A RITTER S THOMSSEN R
Citation
K. Ritter et al., HEMOLYSIS AND AUTOANTIBODIES TO TRIOSEPHOSPHATE ISOMERASE IN A PATIENT WITH ACUTE HEPATITIS-A VIRUS-INFECTION, Scandinavian journal of infectious diseases, 26(4), 1994, pp. 379-382
Citations number
13
Categorie Soggetti
Infectious Diseases
Journal title
Scandinavian journal of infectious diseases → ACNP
ISSN journal
00365548
Volume
26
Issue
4
Year of publication
1994
Pages
379 - 382
Database
ISI
SICI code
0036-5548(1994)26:4<379:HAATTI>2.0.ZU;2-C
Abstract
Having returned from a holiday in Southeast Europe, a 30-year-old Germ an woman developed acute hepatitis. Hepatitis A virus (HAV) infection was diagnosed serologically. During the course of the infection, hemol ysis was found. IgM antibodies against triosephosphate isomerase (IgM anti-TPI) were detected in the patient's serum from the acute phase of the HAV infection. Affinity purified IgM anti-TPI from the serum redu ced the enzyme activity in vitro and caused an increased Cr-51 release from erythrocytes. IgM anti-TPI is assumed to be one of the causative agents of hemolysis in HAV infection.