DEVELOPMENT OF RESISTANCE TO MACROLIDE ANTIBIOTICS IN AN AIDS PATIENTTREATED WITH CLARITHROMYCIN FOR CAMPYLOBACTER-JEJUNI DIARRHEA

In an AIDS patient with diarrhea, identical isolates of Campylobacter jejuni susceptible and, later, resistant to macrolide antibiotics were isolated from feces before and after treatment with clarithromycin. R esults of rRNA gene restriction analysis and serotyping suggest that d evelopment of resistance rather than simultaneous infection with a sus ceptible and a resistant strain was responsible for this phenomenon. T his is the first report of in vivo development of resistance by Campyl obacter jejuni in a patient treated with a macrolide for Campylobacter jejuni infection.