DECREASED DOPAMINE TRANSPORTERS WITH AGE IN HEALTHY-HUMAN SUBJECTS

Authors
VOLKOW ND FOWLER JS WANG GJ LOGAN J SCHLYER D MACGREGOR R HITZEMANN R WOLF AP
Citation
Nd. Volkow et al., DECREASED DOPAMINE TRANSPORTERS WITH AGE IN HEALTHY-HUMAN SUBJECTS, Annals of neurology, 36(2), 1994, pp. 237-239
Citations number
19
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
36
Issue
2
Year of publication
1994
Pages
237 - 239
Database
ISI
SICI code
0364-5134(1994)36:2<237:DDTWAI>2.0.ZU;2-H
Abstract
The effects of aging on brain dopamine transporters was evaluated in 2 6 healthy male volunteers (age range, 21-63 years) using positron emis sion tomography and [C-11]cocaine. The ratio of the distribution volum e for [C-11]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age-related decline in dopamine transporters in h ealthy individuals.