IN-VIVO DETECTION OF MYELIN PHOSPHOLIPIDS IN MULTIPLE-SCLEROSIS WITH PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING

Authors
HUSTED CA MATSON GB ADAMS DA GOODIN DS WEINER MW
Citation
Ca. Husted et al., IN-VIVO DETECTION OF MYELIN PHOSPHOLIPIDS IN MULTIPLE-SCLEROSIS WITH PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING, Annals of neurology, 36(2), 1994, pp. 239-241
Citations number
16
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
36
Issue
2
Year of publication
1994
Pages
239 - 241
Database
ISI
SICI code
0364-5134(1994)36:2<239:IDOMPI>2.0.ZU;2-U
Abstract
The goal of this study was to investigate myelin phospholipids in vivo in multiple sclerosis lesions and normal-appearing white matter by ev aluating the spectral broad component from phosphorus 31 magnetic reso nance spectroscopic imaging data. The phospholipid broad component was reduced nearly 35% (p < 0.001) in both lesions and in normal-appearin g white matter in multiple sclerosis subjects compared to control subj ects, suggesting reduced myelin phospholipid concentration or altered relaxation times.