INTERACTION BETWEEN THE DOMINANT-NEGATIVE MUTANT AND THE WILD-TYPE ENVELOPE PROTEINS OF FRIEND MURINE LEUKEMIA-VIRUS

Interaction between the previously obtained dominant negative mutant, referred to as fcr (T. Matano, T. Odawara, M. Ohshima, H. Yoshikura, a nd A. Iwamoto, J. Virol. 67:2026-2033, 1993), and the wild-type envelo pe proteins (Env) of Friend murine leukemia virus was examined. The wi ld-type Env was bound to the fcr mutant Env and trapped in the endopla smic reticulum. The virus receptor was not involved in this interactio n.