The need for optimal control is increasing due to more emphasis on min
imizing energy use and making products with less variability. We have
seen significant energy savings and decreases in product variability u
sing mechanistic, nonlinear models for control of industrial distillat
ion columns. Steady state and dynamic models of this type could play a
n important role in the future of model predictive control because thi
s type controller works well when process gains change significantly f
rom changes in operating conditions or from nonstationary behavior. Th
is approach also does not require process perturbation tests.