CORRELATION BETWEEN CLINICAL AND HISTOPATHOLOGIC RISK-FACTORS AND LYMPH-NODE METASTASES IN EARLY ENDOMETRIAL CANCER (A MULTIVARIATE-ANALYSIS OF 183 CASES)

This study includes 183 patients with clinical stage I endometrial can cer subjected to peritoneal cytology, total abdominal hysterectomy, bi lateral salpingo-oophorectomy, bilateral pelvic and para-aortic lympha denectomy and omental biopsy during a 12-year period in a single insti tution. The factors analyzed were age, menopausal state, cell type, gr ade, mitotic activity, myometrial invasion, lymphovascular space invas ion, cervical involvement, microscopic vaginal metastases, adnexal met astases, peritoneal cytology, presence of concomitant endometrial hype rplasia and lymph node status. The overall incidences of pelvic and pa ra-aortic lymph node metastases were found to be 15.3% (28/183) and 9. 3% (17/183), respectively. In five of 17 patients (29.4%) with para-ao rtic nodal metastases, pelvic nodes were free of tumor. The most signi ficant prognostic factors for positive pelvic and/or para-aortic nodes were found to be the depth of myometrial invasion, grade of tumor and age.